We already know that current Covid-19 vaccine trials are unlikely to show a reduction in severe illness or deaths.
(Doshi, BMJ 2020;371:m4037, October 21).
Will they be like seasonal influenza vaccines, which have not proved to be lifesavers, and may even have increased overall mortality in the elderly?
(Anderson et al, Ann Intern Med 2020;172:445)
We need a lot more time and a lot more data, especially in view of massive uncertainties about Covid-19 case definitions and statistics.
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